What is PT-141?

PT-141 (bremelanotide) is a synthetic peptide that activates melanocortin receptors in the brain. It was developed from research on melanotan, a peptide originally studied for skin tanning, when investigators observed effects on sexual arousal.

The FDA approved bremelanotide as Vyleesi in 2019 for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women — making it one of the few peptides in this category with a defined, approved clinical indication.

 

Benefits and uses Of PT-141

PT-141 is used for sexual dysfunction in both men and women, with the strongest formal evidence in women:

• Low sexual desire. The FDA-approved indication (as Vyleesi) is HSDD in premenopausal women — low desire that causes distress and is not attributable to another condition or medication.
• Sexual arousal. Because it acts centrally, it is studied for arousal and desire rather than the mechanical, blood-flow effect of PDE5 inhibitors.
• Use in men. PT-141 is used off-label and in research for low libido and sexual dysfunction in men, including cases where blood-flow-targeting drugs are insufficient.

The distinction from Viagra is the key point: PT-141 works through the brain, not the vascular system, which is why it addresses desire rather than only the physical mechanics of erection.

 

Specifications

Other Known Titles: Bremelanotide

Molecular Formula: C₅₀H₆₈N₁₄O₁₀

Molecular Weight: 1025.18 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

 

Dosage and administration

As the FDA-approved Vyleesi, bremelanotide is given by subcutaneous injection with an auto-injector, taken on demand at least 45 minutes before anticipated sexual activity, with a defined maximum dosing frequency.

Nasal administration is also used outside the approved product. Because an approved product with official labeling exists, dosing should follow that labeling or a prescribing provider’s direction — do not extrapolate from informal protocols.

 

Unit Size	10 mg/vial
Unit Quantity	1 Vial
Molecular Formula	C50H68N14O10
Molecular Weight	1025*16
Sequence	Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH)
Appearance	White Powder
Peptide Purity	>99%
Solubility	>Soluble in water or 1% acetic acid
Identity (ESI-MS)	1025.16±1.0
Source	Chemical Synthesis
Storage	Lyophilized Bremelanotide (PT141) is stable at room temperature for 90 days, however it should be stored in a freezer below -8C for any extended period of time. After reconstituting Bremelanotide (PT141) should be refrigerated at temperatures not to exceed 36 F.
WARNING	This product is a lyophilized peptide for research use only. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT in a sterile solution and is NOT to be injected. This product should only be handled by licensed, qualified professionals. If you buy peptides online from us, they are not peptides for bodybuilding. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.